These techniques include free surface electrospinning with 1st. For the purpose of producing a novel guided tissue regeneration membrane with antibacterial activity and osteogenesis, coaxial electrospinning was utilized to manufacture coreshell structure fiber mats. Pdf blend electrospinning, coaxial electrospinning, and emulsion. Pdf superhydrophobic and oleophobic fibers by coaxial. Photocatalytic self cleaning textile fibers by coaxial electrospinning n. Coaxial electrospinning with agno 3 solution as sheath fluid not only facilitates the electrospinning process, providing nanofibers with reduced diameters, but also allows functionalization of the nanofibers through coating with functional ingredients, effectively ensuring that the active antibacterial component is on the surface of the material, which leads to enhanced activity. With the rapid advancement of regenerative medicine technologies, there is an urgent need for the development of new, cellfriendly techniques for obtaining nanofibersthe raw material for an artificial extracellular matrix production. However, the low fluid throughput in singleneedle spinning has limited the industrial use of singleneedle schemes. Control of physical properties of carbon nanofibers obtained from coaxial electrospinning of pmma and. By interchanging the inner and outerchannel solutions, either pdllaphb or phbpdlla core. The accurate prediction and manipulation of nanoscale product sizes is a major challenge in material processing. Coaxial electrospinning coes schematic diagram of a coaxial electrospinning apparatus and a coaxial electrospinneret are shown in fig. Guided tissue regeneration is a standard surgical treatment for periodontal regeneration. Figure 18 shows some primary research of the multiencapsulation and multiresponsive materials in the coreshell nanofibers by coaxial electrospinning.
Preparation by coaxial electrospinning and characterization of membranes releasing. Electrospinning equipments nanofiber machines inovenso. Electrospinning is the most commercially successful process for the production of nanofibers and rising demand is driving research and development in this field. Structure and properties of slowresorbing nanofibers. A series of analyses were undertaken to characterize. Coaxial electrospinning provides the flexible and facilitate method to construct and fabricate diversiform nano or micro encapsulation materials and coreshell nano or micro devices. The distance between the electrospinning nozzle and roller was 18 cm with a high voltage of 16 kv. Coaxial electrospinning is a novel technique that is currently being explored to create such polymer scaffolds by embedding within them aqueousbased biological molecules. Coaxial electrospinning of fluorescein isothiocyanateconjugated bovine serum. A multifunctional coaxial fiber membrane loaded with dual.
Coaxial electrospinning formation of complex polymer fibers and. Coaxial electrospinning formation of complex polymer. Single, coaxial, triaxial and multinozzle spinnerets. Elastic fibers are a fundamental requirement for tissue. Coaxial electrospinning an overview sciencedirect topics. Electrospun nanofibers offers systematic and comprehensive coverage for academic researchers, industry professionals, and postgraduate students working in the field of fiber science. Us20100297906a1 methods for electrospinning hydrophobic. Recently, a coaxial electrospinning process has been used to fabricate new nanostructures with advanced performance, but intricate and delicate process conditions hinder. Coaxial electrospinning and sustained release properties.
Solutions of two biodegradable polymers, that is, polydllactic acid pdlla and poly3hydroxy butyrate phb, were individually delivered to the inner and outer channel of a coaxial tube spinneret for electrospinning to prepare core. In this study, we evaluated the influence of various processing parameters such as sheath polymer concentration, core polymer concentration and molecular weight, and salt. The process does not require the use of coagulation chemistry or high temperatures to. The electrospinning apparatus consists of a coaxial spinneret and a syringe pump new era pump systems ne, farmingdale, ny mounted on a wood stand. We investigated the structure and properties of pcl10 nanofibers, pcl5pcl10 coreshell type nanofibers, as well as pcl5pclag nanofibres prepared by. This is achieved by inserting a thin flexible capillary into the tube through which the main spinning solution is pumped. Coaxial electrospinning for nanostructured advanced. Coaxial nanofibers from polycaprolactone polyvinyl. The development of this method of encapsulation could be very relevant in food items, pharmaceuticals, textile industry, controlled. Photocatalytic self cleaning textile fibers by coaxial. Fibers and particles fabricated by coaxial electrospinning have many applications. Lei jiang for great help on technology and knowledge. Us20180226582a1 us15891,178 us201815891178a us2018226582a1 us 20180226582 a1 us20180226582 a1 us 20180226582a1 us 201815891178 a us201815891178 a us 201815891178a us 2018226582 a1 us2018226582 a1 us 2018226582a1 authority us united states prior art keywords coaxial nanocomposite wt polymer nm prior art date 20170207 legal status the legal status is an.
Versatile coresheath biofibers using coaxial electrospinning. Electrospinning is a fiber production method which uses electric force to draw charged threads of polymer solutions or polymer melts up to fiber diameters in the order of some hundred nanometers. Previously, most of the electrospinning experiments have been carried out using singleneedle arrangements. Biodegradable coreshell fibers by coaxial electrospinning. The use of electrospun nanofibers in drug delivery has increased rapidly over recent years due to their valuable properties, which include a large surface area, high porosity, small pore size, superior mechanical properties, and ease of surface modification. Coaxial electrospinning is also useful for the encapsulation of nonspinnable materials such as nanoparticles or conjugated polymers exhibiting a poor thermoplastic behavior, 114 enzymes, protein, and cells. Coaxial electrospinning is an extended form of electrospinning for the synthesis of composite nanofibers for efficient gene delivery because of the unique structure of coaxial electrospun nanofibers. Coaxial nozzle, where the nozzle comprises of an inner and outer orifice, is often associated with electrospinning coreshell fibers. Electrospun nanofibers for drug delivery systems sigma. Electrospinning is a useful and efficient technique to produce ultrafine. Using a mixed solvent of ethanol and n,ndimethylacetamide as a sheath fluid, the electrospinning of a codissolving solution of diclofenac sodium ds and eudragit l100 el100 could run smoothly and continuously without any clogging.
A modified coaxial electrospinning process was developed for creating drugloaded composite nanofibers. Antioxidant, antibacterialantifungal nanostructures for. If polymer solution with a high concentration can be electrospun into ultrafine fibers, it would inevitably improve the capability of electrospinning and broaden the. Methods for electrospinning a hydrophobic coaxial fiber into a superhydrophobic coaxial fiber mat can include providing an electrospinning coaxial nozzle comprising a core outlet coaxial with a sheath outlet, ejecting an electrospinnable core solution from the core outlet of the electrospinning coaxial nozzle, ejecting a hydrophobic sheath solution from the sheath outlet of the electrospinning.
The outer liquid of a twoliquid coaxial electrified jet is gelled before the onset of natural instabilities to yield hollow nanofibers. A stainless steel roller was used as collecting device. Superhydrophobic and oleophobic fibers by coaxial electrospinning. Steckl1 1department of electrical and computer engineer ing, university of cincinnati, cincinnati, oh, 45221 2department of surgery, university of cincinnati, cincinnati, oh, 45267 abstract we have investigated coaxial electrospinning to produce coresheath fibers for tissue. A common syringe pump controlled the flow rate of the two polymer solutions. Manufacturing of bioreactive nanofibers for bioremediation. In recent years, there has been an increasing interest in. Everyday new publications show different applications for the electrospun nanofibers. Coaxial electrospun freestanding and mechanically stable. Electrospinning, a common method for synthesizing 1d nanostructures, has contributed to developments in the electrical, electrochemical, biomedical, and environmental fields. Aqueousbased coaxial electrospinning of genetically engineered. Oct2010 2 linari engineering solves the problem of stable geometry for coaxial electrospinning with a stainless steel solution able to cut setup and cleaning time with a quick dismountable assembly.
Pdf coaxial electrospun nanostructures and their applications. Steckl, nanoelectronics laboratory, department of electrical and computer engineering, and department of chemical and materials engineering, university of cincinnati, cincinnati, ohio 45221. Coaxial electrospinning differs significantly from emulsioncentered methods in that it generates coresheath fibers by physical separation through the utilization of two electrospinning tips and two solutions. Coaxial electrospinning is an innovatively extended form of electrospinning, which uses two concentrically aligned capillaries to enforce the. Today, with substantial global demand from patients suffering from wounds and burns, the wound care sector has gained great deal of interest in.
Study on the various types of needle based and needleless. Electrospinning has been used extensively to synthesize nanofibers for various applications 4,6,1012 because it allows the precise control over the composition, structure, and mechanical properties of the resulting biomaterial. In this investigation, two process characteristics were explored during the modified coaxial electrospinning of zein, with the aim of understanding how this impacts the products formed. Putting electrospun nanofibers to work for biomedical research. Rutledge1 1 department of chemical engineering, massachusetts institute of technology, cambridge, ma 029 2 department of chemical and materials engineering, california state polytechnic university, pomona, pomona, ca 91768. Versatile coresheath biofibers using coaxial electrospinning daewoo han1, steven t. Two methods are under scrutiny for their capability to encapsulate therapeutic compounds within electrospun nanofibers. Pdf as an innovative extension of electrospinning, coaxial electrospinning could. Electrohydrodynamic ehd compound jets, with diameters in the micro and nanometric size range, from conical menisci of two coflowing liquids, is a consolidated platform for the production of nanofibers with inner structure, in a process socalled coaxial electrospinning or coelectrospinning. Electrospinning shares characteristics of both electrospraying and conventional solution dry spinning of fibers. Coaxial needles for electrospinning linari biomedical. Electrospinning requires a highvoltage power supply, a syringe pump, a polymer solution to be spun, and a grounded collection surface.
Because of this propriety, users of the electrospinning systems prefer to start with smallscale laboratory experiences and scaleup subsequently once succeeded in the researches. Electrospinning is still a new and mysterious field of research with nanofibers. Coaxial electrospinning we work mainly with coaxial electrospining 2, in which one fluid is spun inside another. Without question, the construction of tissue engineering scaffolds and the selection of the scaffold material.
A modified free surface coaxial electrospinning setup was developed figs. The sulfadiazine or sulfadiazine modified chitosan nanoparticles loosely attached at the surface of the nanofibers, could provide a. These include initiation and facilitation of electrospinning, controlling fiber quality, creating hollow fibers and reducing fiber diameter. Electrically forced coaxial nanojets for onestep hollow. Industrial upscaling of electrospinning and applications. The coaxial electrospinning nozzle was a stainless steel nozzle with outer and inner diameter of 1. Pdf blend electrospinning, coaxial electrospinning, and. Nadetech ndes lab electrospinning unit is a completely automatized.
Electrospinning has emerged as one of the potential techniques for producing nanofibers. However, the coaxial nozzle design has many other uses in electrospinning and the production of fibers. One of the most relevant techniques to fabricate polymer nanofibers with unique coresheath or hollow structures micronanocapsules, hollow spheres, hollow fibers and coaxial fibers is the recently discovered coaxial electrospinning and electrospray technique. Coaxial electrospinning is an effective method for the preparation of hollow nanofibers and tissue engineering scaffolds, and the core and shell materials can be selected judiciously to meet the requirements for various applications. Pdf on jan 1, 2018, matej buzgo and others published blend electrospinning, coaxial electrospinning, and emulsion electrospinning techniques find, read and cite all the research you need on. A logical next step is the inclusion of certain molecules and compounds to accelerate or increase the efficacy of tissue regeneration. The characteristics studied were the spreading angle at the unstable region. In particular, coaxial electrospinning, which forms fibers with multiple core. Production of coreshell fibers by electrospinning from a free surface keith m.
They are also grateful to the chinese academy of sciences. A cellfree nanofiber composite scaffold regenerated. The capillary, through which the inner fluid is pumped, is positioned such that it runs coaxially inside the. A modified coaxial electrospinning for preparing fibers from a high. A study of free surface electrospinning process to enhance. Polymers free fulltext the relationships between the. Production of coreshell fibers by electrospinning from a. Solutions of two biodegradable polymers, that is, polydllactic acid pdlla and poly3hydroxy butyrate phb, were individually delivered to the inner and outer channel of a coaxialtube spinneret for electrospinning to prepare core. As an evolution of conventional electrospinning, coaxial electrospinning became popular soon after its debut as a novel way to develop nanofibers with special structures, such as coreshell and hollow interior. Steckl, nanoelectronics laboratory, department of electrical engineering and computing systems, university of cincinnati, cincinnati, ohio 45221, united states department of chemistry, university of cincinnati.
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